Continuous Improvement of Responsible Care Activities

Management of Chemical Substances


During the World Summit on Sustainable Development (WSSD) held in 2002, the "2020 goal" were agreed upon to minimize the negative impact on people's health and environment caused by the production and use of chemicals. This was an effort taken to ensure that chemical products do not cause health damage or adverse effects on the environment through safe production, transportation, use, consumption, and disposal. To achieve the "2020 goal", the "Strategic Approach to International Chemicals Management (SAICM)" for promoting risk reduction based on scientific risk assessment, collection and provision of information, and other measures were adopted at the "International Conference on Chemicals Management (ICCM)" in 2006.

At Nissan Chemical, through responsible care activity, we strive to minimize the negative impact of chemical products on people’s health and the environment during their lifecycle in line with the domestic SAICM implementation plan.

Chemicals Management




Risk Assessment in Products Lifecycle

We perform a risk assessment (prior assessment) of each step in handling chemical products, such as the research and development, manufacture, sales and revision. The assessment of risks to human health and the environment in the value chain is based on data performed by the Biological Research Laboratories, either on its own or by outsourcing, safety test data obtained from results of searching external databases such as literature, and checking things such as data on physicochemical properties and work environment conditions. Based on the results of risk assessment, we avoid using chemicals of concern and study safe alternatives.

These results are reported to top management and made known to all the relevant people in the Company. The results are also made known to people in the value chain by means such as technology transfer documents and safety data sheets (SDSs).

Besides, we participate in Long-Range Research Initiative, an international initiative promoted by Japan Chemical Industry Association (JCIA) that seeks to provide long-term support for research on the impact of chemicals on human health and the environment. The activities we engage in aim to advance research on the assessment of risks to human health and the environment.

Disclosure of SDS of Products

To ensure that our chemical products are used safely by our customers, we provide SDSs of all products. Customers and users can download the SDSs for all agrochemicals from our website ( Our employees can obtain information about risks and hazards, laws and regulations, transportation, storage and methods of disposal of products from our internal SDS database for safety and compliance.

Disclosure of GPS Safety Summary of Chemical Substances

For minimizing the risks of chemical substances throughout the entire value chain, we participate in the GPS※1 / JIPS※2 activities promoted by the International Council of Chemical Association (ICCA) and JCIA. As part of our activities, we conduct risk assessments of our chemical products, conduct appropriate risk-based management, and provide safety information. The Information is compiled in GPS / JIPS Safety Summary and made available to the society.

  • 1 Global Product Strategy
  • 2 Japan Initiative of Product Stewardship

Consideration for Animal Testing

Assessment made using laboratory animals is essential for the research and development of agrochemicals, pharmaceuticals, medical materials and chemical materials that are beneficial for society. Biological Research Laboratories has established Animal Testing Guideline of Nissan Chemical in accordance with the Three Rs principles of animal welfare (Replacement with alternative methods, Reduction in the use of laboratory animals and Refinement of methods for reducing pain), and laws and regulations such as the “Act on Welfare and Management of Animals”. Following this guideline, the Institutional Animal Care and Use Committee examines whether to conduct animal testing, both ethically and scientifically, and checks how the tests are performed to ensure that animal testing is conducted appropriately and that proper consideration is given to animal welfare.

Due to these initiatives, the Biological Research Laboratories has obtained third-party certification of its laboratory animal facilities from Japan Health Sciences Foundation.

TOPICS : Introduction of a New Alternative to Skin Sensitization Tests

Recent years have been seen growing concern about animal protection, and the development of alternative test methods that do not use laboratory animals has been actively promoted. The amino acid derivative reactivity assay (ADRA) is a new alternative to skin sensitization tests that was developed by Fujifilm Corporation. Validation tests of this method are being conducted to have it included in the OECD Test Guidelines, with the support of LRI of JCIA. We participate in this test to support the research. We have also completed the introduction of technologies for this test method, ahead of other companies, to the Safety Research Department of the Biological Research Laboratories.

Introduction of a New Alternative to Skin Sensitization Tests


TOPICS :New Initiative to Wastewater Assessment

Since industrial effluents are directly released to the environment, reference values are set for each hazardous substance and released to the environment after they are cleared. However, this management method does not confirm the impacts on aquatic organisms and does not comprehensively assess wastewater. Currently, water environmental management methods using aquatic organisms are being studied in Japan. WET (Whole Effluent Toxicity) enables to assess the impacts of chemical substances in wastewater comprehensively by raising aquatic organisms in wastewater and clarifying their effect on the biological body. The Biological Research Laboratories has applied the evaluation technology for aquatic organisms cultivated through product safety assessments, and has begun initiatives to introduce WET that incorporates the viewpoint of organisms into plant effluent assessment.

New Initiative to Wastewater Assessment




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